高慧玲

发布者:系统管理员编辑:365体育官网app下载 发布时间:2013-08-23浏览次数:13638

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?????? 高慧玲博士,现任365体育在线官网神经科学研究所副教授,硕士研究生导师。2013年在日本爱媛大学获得博士学位。承担国家自然科学基金青年基金项目1项,发表SCI收录期刊论文11篇,其中第一作者发表SCI收录期刊论文6篇。

?科研方向?

?????? 脑锌代谢与学习记忆以及神经退行性疾病发病机理的研究。应用转基因小鼠模型和细胞模型,探讨金属离子及其转运体调节脑内金属离子代谢的分子机制。?

主持基金项目

?????? 国家自然科学基金青年基金项目:D-青霉胺抑制阿尔茨海默病转基因小鼠脑内β-淀粉样蛋白沉积及其机制研究 (81301102)

代表性论文

1.??Hui-Ling Gao, Cheng Li, Nabeka Hiroaki, Shimokawa Tetsuya, Saito Shouichiro, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. Attenuation of MPTP/MPP Toxicity in vivo and in vitro by an 18-mer peptide derived from Prosaposin. Neuroscience. 236:373–393, 2013.

2. Hui-Ling Gao, Cheng Li, Hiroaki Nabeka, Tetsuya Shimokawa, Naoto Kobayashi, Shouichiro Saito, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. Decrease in prosaposin in the dystrophic mdx mouse brain. PLoS ONE. 8(11):?e80032, 2013.?

3. ?Hui-Ling Gao, He Xu, Na Xin, Wei Zheng, Zhi-Hong Chi, Zhan-You Wang. Disruption of the CaMKII/CREB signaling is associated with zinc deficiency-induced learning and memory impairments. Neurotoxicity Research. 19:584–591, 2011.

4. ?Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Zhen-Yu Wang, Jie Chen, Zhan-You Wang. Zinc deficiency reduces neurogenesis accompanied by neuronal apoptosis through caspase-dependent and -independent signaling pathways. Neurotoxicity Research. 16 (4):416-425, 2009.

5. ?Hui-Ling Gao, Wan-Yu Feng, He Xu, Liping Huang, Zhan-You Wang. Golgi apparatus localization of ZNT7 in the mouse cerebellum. Histology and Histopathology. 24 (5):567-572, 2009.

6. ?Hui-Ling Gao, Xin Wang, Wei Zheng, Annica Dahlstrom, Liping Huang, Zhan-You Wang. Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic Neuroscience. 140 (1-2):59-65, 2008.

7. ?Cheng Li, Hui-Ling Gao, Tetsuya Shimokawa, Hiroaki Nabeka, Fumihiko Hamada, Hiroaki Araki, Ya-ming Cao, Naoto Kobayashi and Seiji Matsuda. Prosaposin expression in the regenerated muscles of mdx and cardiotoxin-treated mice. Histology and Histopathology. 28(7):875-892, 2013.

8. He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wang. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus. 21(5):495-501, 2011.

9. ?Bing Xue, Jie Chen, Hui-Ling Gao, Shouichiro Saito, Naoto Kobayashi, Tetsuya Shimokawa, Hiroaki Nabeka, Akira Sano, Seiji Matsuda. Chronological changes in prosaposin in the developing rat brain. Neuroscience Research. 71(1):22-34, 2011.

10. ?Xue-jiao Zhang, Cheng Li, Hui-Ling Gao, Hiroaki Nabeka, Tetsuya Shimokawa, Hir