高慧玲

时间:2013-08-23浏览:12989

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?????? 高慧玲博士,现任365体育在线官网神经科学研究所副教授,硕士研究生导师。2013年在日本爱媛大学获得博士学位。承担国家自然科学基金青年基金项目1项,发表SCI收录期刊论文11篇,其中第一作者发表SCI收录期刊论文6篇。

?科研方向?

?????? 脑锌代谢与学习记忆以及神经退行性疾病发病机理的研究。应用转基因小鼠模型和细胞模型,探讨金属离子及其转运体调节脑内金属离子代谢的分子机制。?

主持基金项目

?????? 国家自然科学基金青年基金项目:D-青霉胺抑制阿尔茨海默病转基因小鼠脑内β-淀粉样蛋白沉积及其机制研究 (81301102)

代表性论文

1.??Hui-Ling Gao, Cheng Li, Nabeka Hiroaki, Shimokawa Tetsuya, Saito Shouichiro, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. Attenuation of MPTP/MPP Toxicity in vivo and in vitro by an 18-mer peptide derived from Prosaposin. Neuroscience. 236:373–393, 2013.

2. Hui-Ling Gao, Cheng Li, Hiroaki Nabeka, Tetsuya Shimokawa, Naoto Kobayashi, Shouichiro Saito, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. Decrease in prosaposin in the dystrophic mdx mouse brain. PLoS ONE. 8(11):?e80032, 2013.?

3. ?Hui-Ling Gao, He Xu, Na Xin, Wei Zheng, Zhi-Hong Chi, Zhan-You Wang. Disruption of the CaMKII/CREB signaling is associated with zinc deficiency-induced learning and memory impairments. Neurotoxicity Research. 19:584–591, 2011.

4. ?Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Zhen-Yu Wang, Jie Chen, Zhan-You Wang. Zinc deficiency reduces neurogenesis accompanied by neuronal apoptosis through caspase-dependent and -independent signaling pathways. Neurotoxicity Research. 16 (4):416-425, 2009.

5. ?Hui-Ling Gao, Wan-Yu Feng, He Xu, Liping Huang, Zhan-You Wang. Golgi apparatus localization of ZNT7 in the mouse cerebellum. Histology and Histopathology. 24 (5):567-572, 2009.

6. ?Hui-Ling Gao, Xin Wang, Wei Zheng, Annica Dahlstrom, Liping Huang, Zhan-You Wang. Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic Neuroscience. 140 (1-2):59-65, 2008.

7. ?Cheng Li, Hui-Ling Gao, Tetsuya Shimokawa, Hiroaki Nabeka, Fumihiko Hamada, Hiroaki Araki, Ya-ming Cao, Naoto Kobayashi and Seiji Matsuda. Prosaposin expression in the regenerated muscles of mdx and cardiotoxin-treated mice. Histology and Histopathology. 28(7):875-892, 2013.

8. He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wang. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus. 21(5):495-501, 2011.

9. ?Bing Xue, Jie Chen, Hui-Ling Gao, Shouichiro Saito, Naoto Kobayashi, Tetsuya Shimokawa, Hiroaki Nabeka, Akira Sano, Seiji Matsuda. Chronological changes in prosaposin in the developing rat brain. Neuroscience Research. 71(1):22-34, 2011.

10. ?Xue-jiao Zhang, Cheng Li, Hui-Ling Gao, Hiroaki Nabeka, Tetsuya Shimokawa, Hiroyuki Wakisaka, Seiji Matsuda, Naoto Kobayashi Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity. Cell and Molecular Biology Letters. 16(2):279-95, 2010.

11. ?Zhi-Hong Chi, Wan-Yu Feng, Hui-Ling Gao, Wei Zheng, Liping Huang and Zhan-You Wang. ZNT7 and Zn2+ are present in different cell populations in the mouse testis. Histology and Histopathology. 24: 25-30, 2009.?

联系方式

  1. 地址:沈阳市沈河区文化东路89号,365体育在线官网神经科学研究所
  2. 邮编:110015
  3. E-mail: ghllch@hotmail.com
  4. 办公电话:024-83656112
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